Acne: perché possono essere utili dermocosmetici e nutraceutici

Per il trattamento dell’acne (1) due recenti articoli del Journal of Drugs in Dermatology forniscono interessanti informazioni sul contributo della dermocosmesi e della nutraceutica, durante e dopo le terapie farmacologiche di questa malattia infiammatoria della pelle (2, 3).

Prodotti di alta qualità e ben formulati possono proteggere e migliorare la barriera cutanea, l’idratazione e la presenza dei batteri benefici che popolano la superficie della pelle, il cosiddetto microbiota cutaneo (Nota 1) (2, 3).

L’acne necessita di appropriate cure dermatologiche, ed anche, a seguito di approvazione medica, dell’uso di detergenti, dermocosmetici ed integratori.

Fenomeni all’origine dell’acne

L’infiammazione, lo stress ossidativo ed altri meccanismi molecolari sono all’origine dell’acne (4-8).

Questi fenomeni sono acutizzati da alterazioni ormonali, metaboliche e da fattori esterni come inquinanti ambientali, fumo di sigaretta, consumo alcol, alimenti ad alto indice glicemico, cibi ultra-processati ecc. (4, 9, 10, 11-20).

Anche le difese antiossidanti dell’organismo risultano molto ridotte nelle persone affette da acne, una condizione che aggrava ulteriormente la malattia (4, 7, 17, 18, 19).

Barriera cutanea, microbiota cutaneo ed intestinale 

Proteggere e riparare l’integrità della barriera cutanea permette di ottimizzare lo scudo protettivo della parte più esterna della pelle, dotato di capacità antibatteriche, antiossidanti, immunitarie e fotoprotettive (2, 3, 25-28).

Per questo le più recenti raccomandazioni cliniche consigliano detergenti ed idratanti cutanei con pH fisiologico (4,70 - 5,75) e con specifici ingredienti attivi, adatti a rispettare e creare le migliori condizioni per l’equilibrio della barriera cutanea e del microbiota cutaneo (2, 3, 4, 26-30). 

Il microbiota cutaneo, come quello intestinale (Nota 1), può essere danneggiato da inquinanti atmosferici, disturbi metabolici come l’iperglicemia e l’obesità, dal consumo di alcol e di alimenti ultra-processati, (4, 26,  29-36), e dall’abbassamento delle difese antiossidanti  dell’organismo (37).

Le alterazioni di questi batteri benefici innescano ed aumentano l’infiammazione dell’organismo (38-42) con aggravamenti dell’acne e rischio di altre complicazioni, riguardanti anche l’intero organismo (12, 14, 34, 38, 43-49, 50-54).

Per questo, anche nell’acne esistono prove cliniche sui benefici dell’apporto di antiossidanti / antinfiammatori derivanti dall’alimentazione (4, 86) e/o da determinati nutraceutici, oltre alla somministrazione mirata di probiotici e prebiotici (4, 34, 55-73, 86-89).

Ulteriori benefici provengono dalla corretta assunzione di vitamina C, D, E (4, 74, 75, 76) e di vitamine del gruppo B (77-81).

Dermocosmetici e nutraceutici Mitochon srl

La linea di dermocosmetici e nutraceutici studiata dalla ricerca Mitochon srl (Nota 2) per l’antiaging cutaneo e sistemico, ha interessanti requisiti per inserirsi nel trattamento dei disturbi infiammatori della pelle (82-85, 90), inclusa l’acne (1, 2, 27).

Tra gli ingredienti attivi troviamo componenti con un alto numero di prove cliniche ed elevata sicurezza, come antiossidanti (es.: precursori di vitamina C, coenzima Q10), polifenoli (es.: resveratrolo), retinoidi (90) (Nota 2).

La linea cosmeceutica (Nota 2) permette di rispettare il pH fisiologico, ed apportare sostanze che riducono l’infiammazione cutanea e le conseguenti complicazioni locali e sistemiche (12, 14, 25, 82-85).

Questi prodotti forniscono componenti indispensabili per l’integrità della barriera cutanea, per riattivare il metabolismo e le funzioni delle cellule cutanee, e innalzare le difese antiossidanti della pelle (12, 14, 25, 82-85).

Ulteriore vantaggio, la presenza di fattori di protezione solare (SPF 30 emulsione giorno; SPF 6 siero concentrato), ed ingredienti utili per prevenire e ridurre l’iperpigmentazione post-infiammatoria, es.: precursori dell’acido ascorbico (91).

L’integratore orosolubile Mitofast® (Nota 2) incrementa le difese antiossidanti dell’organismo (92), necessarie per combattere i meccanismi ossido-infiammatori presenti nell’acne, che minacciano la salute della pelle e dell’intero organismo (15, 16, 51, 93, 94, 95).

Per questo gli ingredienti attivi selezionati dalla ricerca Mitochon srl permettono di migliorare nel tempo la salute cutanea (92, 96, 97) e lo stato di benessere generale (92, 98-101-110).

Conclusioni

L’acne è una malattia che necessita cure dermatologiche, con appropriati trattamenti farmacologici, per scongiurare il rischio di complicazioni cutanee e sistemiche, ed inestetismi permanenti, come cicatrici e discromie cutanee.

Secondo le più recenti prove cliniche, specifici dermocosmetici e nutraceutici possono contribuire a proteggere e migliorare le condizioni della pelle durante i necessari trattamenti farmacologici dell’acne e nella fase di mantenimento dopo la guarigione.

I pazienti con acne devono comunque sempre valutare con il proprio curante l’uso di qualsiasi dermocosmetico e nutraceutico.

Nota 1

Microbiota cutaneo ed intestinale secondo le più recenti acquisizioni *di biologia molecolare e metagenomica rappresentano la popolazione di microrganismi presente sulla superficie cutanea e nell’intestino. Ne fanno parte batteri, virus, funghi ecc.

La loro composizione dipende da molteplici fattori esterni ed interni all’organismo.

L’alterazione del microbiota intestinale (es.: disbiosi) può influenzare l’omeostasi di organi e sistemi, oltre ad essere implicata nell’accelerazione invecchiamento biologico dell’organismo.

Microbioma rappresenta il patrimonio genetico del microbiota, che determina le funzioni dei microrganismi del microbiota, come la modulazione immunitaria, la sintesi di vitamine ecc. 

* Human Microbiome Project (HMP) https://commonfund.nih.gov/hmp

Nota 2

Prodotti antiaging Mitochon srl

•   la linea cosmeceutica è stata studiata per proteggere - rigenerare le attività delle cellule cutanee e ridurre i segni dell’invecchiamento, attraverso l’effetto complessivo di: coenzima Q10, acido folico, precursori della vitamina C, N-acetilglucosamina (NAG) precursore di acido ialuronico, glutatione, tocoferolo, retinil palmitato, ceramidi, acidi grassi ecc.;

•   gli integratori Mitofast® e Mitofast B12 , attenuano i fenomeni biomolecolari dell’invecchiamento cutaneo e sistemico, incluso quello del sistema nervoso centrale.

•   Mitofast® è una formulazione orosolubile, bilanciata e sinergica di: resveratrolo, coenzima Q10, acido folico, vitamina C, N-acetilcisteina (NAC) precursore di glutatione, N-acetilglucosamina (NAG) per la sintesi di acido ialuronico. 

•   Mitofast B12 è un integratore liquido studiato per somministrare in modo mirato la cianocobalamina, la forma di vitamina B12 farmacologicamente più adatta per l’uso orale.

Bibliografia

1. Keri JE, Merola JF. Acne vulgaris. Manuale MSD versione per professionisti. Apr. 2024 https://www.msdmanuals.com/it/professionale/disturbi-dermatologici/acne-e-disturbi-correlati/acne-vulgaris

2. Baldwin H, Bui H, Callender V, Frey C, Hebert A, Ted E, Rieder E, Schlesinger T. The Use of Acneceuticals to Improve Acne Care: Introduction of a New Term and Review of the Literature. J Drugs Dermatol. 2025 Mar 1;24(3):281-288. doi: 10.36849/JDD.8817. 

3. Baldwin H, Frey C, Hebert A, Ted Lain E, Schlesinger T. An Algorithm Integrating Acneceuticals into the Management of Acne Vulgaris. J Drugs Dermatol. 2025 Apr 1;24(4):376-380. doi: 10.36849/JDD.8887.

4. Bungau AF, Radu AF, Bungau SG, Vesa CM, Tit DM, Endres LM. Oxidative stress and metabolic syndrome in acne vulgaris: Pathogenetic connections and potential role of dietary supplements and phytochemicals. Biomed Pharmacother. 2023 Aug;164:115003. doi: 10.1016/j.biopha.2023.115003

5. Yang X, Wang X, Yang J. Single-cell analysis reveals cellular heterogeneity, gene expression profiles, and pathway dynamics in acne vulgaris. Arch Dermatol Res. 2025 Feb 7;317(1):362. doi: 10.1007/s00403-025-03894-9. 

6. Bhoi S, Das K, Meher P, Panda B, Acharya M, Barik D, Pandey M. Serum High-sensitive C-Reactive Protein, Interleukin-6 and Malondialdehyde Levels in Acne Vulgaris and Their Correlation With Disease Severity: A Cross-Sectional Study. Cureus. 2025 Jul 21;17(7):e88405. doi: 10.7759/cureus.88405. 

7. Su L, Wang F, Wang Y, Qin C, Yang X, Ye J. Circulating biomarkers of oxidative stress in people with acne vulgaris: a systematic review and meta-analysis. Arch Dermatol Res. 2024 Mar 15;316(4):105. doi: 10.1007/s00403-024-02840-5.

8. Vasam M, Korutla S, Bohara RA. Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochem Biophys Rep. 2023 Nov 23;36:101578. doi: 10.1016/j.bbrep.2023.101578.

9. Chen T, Chen Y, Shao X, Chen J, Liu L, Li Y, Pu Y, Chen J. Hematological parameters in patients with acnes. J Cosmet Dermatol. 2023 Jul;22(7):2099-2104. doi: 10.1111/jocd.15676. 

10. Xiao Q, Rang Z, Liu S, Wang Y, Ma Y, Zhang Y, Lv Y, Ye J, Wang Q, Liu W. Two distinct patterns of acne progression: Pathogenesis and implications for management. J Am Acad Dermatol. 2025 Jul;93(1):234-237. doi: 10.1016/j.jaad.2025.02.060.

11. Barrea L, et Al. Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), the Italian Society of Dermatology and Sexually Transmitted Diseases (SIDeMaST), the Italian Society of Nutraceuticals (SINut), Club Ketodiets and Nutraceuticals "KetoNut-SINut" and the Italian Society of Endocrinology (SIE), Club Nutrition, Hormones and Metabolism. Curr Obes Rep. 2025 May 13;14(1):42. doi: 10.1007/s13679-025-00630-2. 

12. Mini-Review Pelle - Infiammazione cronica 2025 https://www.mitochon.it/la-pelle-come-scudo-contro-linfiammazione-cronica-dellorganismo/?v=0d149b90e739

13. Mini-Review AGEs - invecchiamento cutaneo 2025 https://www.mitochon.it/invecchiamento-cutaneo-e-prodotti-della-glicazione-avanzata-ages-4-possibili-strategie-per-combatterli/?v=0d149b90e739

14. Mini-Review Cellule cutanee - senescenza 2024 https://www.mitochon.it/le-ultime-scoperte-sullattivita-dei-mitocondri-cellule-cutanee-bersagli-e-risultati-dellantiaging-mitocondriale/

15. Mini-Review Sovrappenso / Obesità - Resveratrolo - Antiossidanti 2025 https://www.mitochon.it/sovrappeso-obesita-quale-contributo-dal-resveratrolo-ed-altri-antiossidanti/?v=0d149b90e739

16. Mini-Review Sindrome Metabolica 2024 https://www.mitochon.it/sindrome-metabolica-2024-dalle-origini-molecolari-al-ruolo-dei-nutraceutici/

17. Popa GL, Mitran CI, Mitran MI, Tampa M, Matei C, Popa MI, Georgescu SR. Markers of Oxidative Stress in Patients with Acne: A Literature Review. Life (Basel). 2023 Jun 23;13(7):1433. doi: 10.3390/life13071433. 

18. Md Jaffri J. Reactive Oxygen Species and Antioxidant System in Selected Skin Disorders. Malays J Med Sci. 2023 Feb;30(1):7-20. doi: 10.21315/mjms2023.30.1.2. 

19. Goyal A, et Al Status of Oxidants and Antioxidants in Acne Vulgaris: A Cross-sectional Study. Journal of Clinical and Diagnostic Research. 2025 May, Vol-19(5): BC01-BC04

20. Han HS, Seok J, Park KY. Air Pollution and Skin Diseases. Ann Dermatol. 2025 Apr;37(2):53-67. doi: 10.5021/ad.24.159.

21. Mosca, S.; Ottaviani, M.; Briganti, S.; Di Nardo, A.; Flori, E. The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases. Cells 2025, 14, 747. https://doi.org/10.3390/cells14100747

22. Jin H, Lin Z, Pang T, Wu J, Zhao C, Zhang Y, Lei Y, Li Q, Yao X, Zhao M, Lu Q. Effects and mechanisms of polycyclic aromatic hydrocarbons in inflammatory skin diseases. Sci Total Environ. 2024 May 15;925:171492. doi: 10.1016/j.scitotenv.2024.171492. Epub 2024 Mar 6. Erratum in: Sci Total Environ. 2024 May 20;926:172074. doi: 10.1016/j.scitotenv.

23. Chen X, Wen J, Wu W, Tu Y, Peng Q, Tao S, Yang H, He L. Non-linear association between air pollutants and secondary sensitive skin in acne patients. J Cosmet Dermatol. 2024 Dec;23(12):4007-4016. doi: 10.1111/jocd.16487.

24. Kleemann J, Cinatl J Jr, Hoffmann S, Zöller N, Özistanbullu D, Zouboulis CC, Kaufmann R, Kippenberger S. Alcohol Promotes Lipogenesis in Sebocytes-Implications for Acne. Cells. 2024 Feb 11;13(4):328. doi: 10.3390/cells13040328. 

25. Mini-Review Antiaging cutaneo - ruolo dei lipidi cutanei 2025 https://www.mitochon.it/antiaging-cutaneo/?v=0d149b90e739

26. Del Rosso JQ, Kircik L. Skin 101: Understanding the Fundamentals of Skin Barrier Physiology-Why is This Important for Clinicians? J Clin Aesthet Dermatol. 2025 Feb;18(2):7-15.

27. Thiboutot D, Layton AM, Traore I, Gontijo G, Troielli P, Ju Q, Kurokawa I, Dreno B. International expert consensus recommendations for the use of dermocosmetics in acne. J Eur Acad Dermatol Venereol. 2025 May;39(5):952-966. doi: https://onlinelibrary.wiley.com/doi/10.1111/jdv.20145

28. Deng Y, Wang F, He L. Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches. Med Sci Monit. 2024 Dec 13;30:e945336. doi: 10.12659/MSM.945336.

29. Yue X, Wang H, Xu YN, Chu CC, Chen L. Microbiome network: a robust biomarker of skin health. Br J Dermatol. 2025 Oct 21;193(Supplement_2):ii1-ii5. doi: 10.1093/bjd/ljaf230.

30. Kreouzi M, Theodorakis N, Nikolaou M, Feretzakis G, Anastasiou A, Kalodanis K, Sakagianni A. Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease. Microorganisms. 2025 Jan 14;13(1):161. doi: 10.3390/microorganisms13010161.

31. Searle T, Al-Niaimi F, Ali FR. Modulation of the microbiome: a paradigm shift in the treatment of acne. Clin Exp Dermatol. 2025 Jul 18:llaf328. doi: 10.1093/ced/llaf328.

32. Podwojniak A, Tan IJ, Sauer J, Neubauer Z, Rothenberg H, Ghani H, Parikh AK, Cohen B. Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments. J Eur Acad Dermatol Venereol. 2025 Apr;39(4):793-805. doi: 10.1111/jdv.20332.

33. Li X, Jin J. The Mechanism and Research Progress of Skin Microbiota in Pathogenesis of Acne. Dermatol Res Pract. 2025 Oct 14;2025:9910076. doi: 10.1155/drp/9910076.

34. Ilari S, Nucera S, Morabito L, Caminiti R, Mazza V, Ritorto G, Ussia S, Passacatini LC, Macrì R, Scarano F, Serra M, Scali E, Maiuolo J, Oppedisano F, Palma E, Muscoli S, Proietti S, Tomino C, Mollace V, Muscoli C. A Systematic Review of the Effect of Polyphenols on Alterations of the Intestinal Microbiota and Shared Bacterial Profiles Between Metabolic Syndrome and Acne. Nutrients. 2024 Oct 23;16(21):3591. doi: 10.3390/nu16213591. 

35. Rondinella, D.; Raoul, P.C.; Valeriani, E.; Venturini, I.; Cintoni, M.; Severino, A.; Galli, F.S.; Mora, V.; Mele, M.C.; Cammarota, G.; et al. The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier. Nutrients 2025, 17, 859. https://doi.org/10.3390/nu17050859

36. Scharschmidt TC, Segre JA. Skin microbiome and dermatologic disorders. J Clin Invest. 2025 Feb 3;135(3):e184315. doi: 10.1172/JCI184315.

37. Ramos-León J, Valencia C, Gutiérrez-Mariscal M, Rivera-Miranda DA, García-Meléndrez C, Covarrubias L. The loss of antioxidant activities impairs intestinal epithelium homeostasis by altering lipid metabolism. Exp Cell Res. 2024 Apr 1;437(1):113965. doi: 10.1016/j.yexcr.2024.113965. 

38. Cao Q, Guo J, Chang S, Huang Z, Luo Q. Gut microbiota and acne: A Mendelian randomization study. Skin Res Technol. 2023 Sep;29(9):e13473. doi: 10.1111/srt.13473.

39. Di Vincenzo F, Del Gaudio A, Petito V, Lopetuso LR, Scaldaferri F. Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Intern Emerg Med. 2024 Mar;19(2):275-293. doi: 10.1007/s11739-023-03374-w. 

40. Escalante J, Artaiz O, Diwakarla S, McQuade RM. Leaky gut in systemic inflammation: exploring the link between gastrointestinal disorders and age-related diseases. Geroscience. 2025 Feb;47(1):1-22. doi: 10.1007/s11357-024-01451-2.

41. Neurath MF, Artis D, Becker C. The intestinal barrier: a pivotal role in health, inflammation, and cancer. Lancet Gastroenterol Hepatol. 2025 Jun;10(6):573-592. doi: 10.1016/S2468-1253(24)00390-X. 

42. Chancharoenthana W, Kamolratanakul S, Udompornpitak K, Wannigama DL, Schultz MJ, Leelahavanichkul A. Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner. Sci Rep. 2025 Apr 27;15(1):14710. doi: 10.1038/s41598-025-97593-0.

43. Pai VV, Sarath AP, Kerkar Z. Gut microbiome in dermatology - A narrative review. Indian J Dermatol Venereol Leprol. 2025 Mar 4:1-11. doi: 10.25259/IJDVL_1094_2024.

44. Maria Fernanda Sanchez-Lopez, Paula Alejandra Barrero-Caicedo, Helen Melissa Olmos-Carval, Andres Felipe Torres-Medina, Juan Pablo Alzate-Granados, Relationship between skin and gut microbiota dysbiosis and inflammatory skin diseases in adult patients: A systematic review, The Microbe, Volume 7, 2025, https://doi.org/10.1016/j.microb.2025.100342.

45. Sánchez-Pellicer, P.; Navarro-Moratalla, L.; Núñez-Delegido, E.; Ruzafa-Costas, B.; Agüera-Santos, J.; Navarro-López, V. Acne, Microbiome, and Probiotics: The Gut–Skin Axis. Microorganisms 2022, 10, 1303. https://doi.org/10.3390/microorganisms10071303

46. Zhao Y, Yu C, Zhang J, Yao Q, Zhu X, Zhou X. The gut skin axis: Emerging insights in understanding and treating skin diseases through gut microbiome modulation (Review). Int J Mol Med. 2025 Dec;56(6):210. doi: 10.3892/ijmm.2025.5651.

47. Jimenez-Sanchez M, Celiberto LS, Yang H, Sham HP, Vallance BA. The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential. Gut Microbes. 2025 Dec;17(1):2473524. doi: 10.1080/19490976.2025.2473524.

48. Haidar, L.; Bănărescu, C.F.; Uța, C.; Zimbru, E.-L.; Zimbru, R.-I.; Tîrziu, A.; Pătrașcu, R.; Șerb, A.-F.; Georgescu, M.; Nistor, D.; et al. Beyond the Skin: Exploring the Gut–Skin Axis in Chronic Spontaneous Urticaria and Other Inflammatory Skin Diseases. Biomedicines 2025, 13, 2014. https://doi.org/10.3390/biomedicines13082014

49. He, X., Zhang, Z., Jiang, H. et al. Causal association of gut microbes and blood metabolites with acne identified through systematic mendelian randomization. Sci Rep 14, 26816 (2024). https://doi.org/10.1038/s41598-024-78603-z

50. Agostini D, Bartolacci A, Rotondo R, De Pandis MF, Battistelli M, Micucci M, Potenza L, Polidori E, Ferrini F, Sisti D, Pegreffi F, Pazienza V, Virgili E, Stocchi V, Donati Zeppa S. Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights. Nutrients. 2025 Apr 11;17(8):1325. doi: 10.3390/nu17081325.

51. Mini-Review Vitamine complesso B - microbiota 2024  https://www.mitochon.it/le-vitamine-del-gruppo-b-cosa-ce-di-nuovo-parte-2/

52. Mini-Review Vitamina B12 - Acido Folico 2024 https://www.mitochon.it/vitamina-b12-e-acido-folico-cosa-ce-di-nuovo-parte-1/

53. Lee, H.-J.; Kim, M. Skin Barrier Function and the Microbiome. Int. J. Mol. Sci. 2022, 23, 13071. https://doi.org/10.3390/ijms232113071

54. Qiao L, Yang G, Wang P, Xu C. The potential role of mitochondria in the microbiota-gut-brain axis: Implications for brain health. Pharmacol Res. 2024 Nov;209:107434. doi: 10.1016/j.phrs.2024.107434.

55.Eguren C, Navarro-Blasco A, Corral-Forteza M, Reolid-Pérez A, Setó-Torrent N, García-Navarro A, Prieto-Merino D, Núñez-Delegido E, Sánchez-Pellicer P, Navarro-López V. A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris. Acta Derm Venereol. 2024 May 15;104:adv33206. doi: 10.2340/actadv.v104.33206.

56.  Liang L, Qi X, Jiang X, Chen T and Dong L (2024) Lactobacillus plantarum MH-301 as an effective adjuvant to isotretinoin in the treatment of acne vulgaris: a randomized and open-label trail. Front. Med. 10:1340068. doi: 10.3389/fmed.2023.1340068

57. De Almeida, C.V.; Antiga, E.; Lulli, M. Oral and Topical Probiotics and Postbiotics in Skincare and Dermatological Therapy: A Concise Review. Microorganisms 2023, 11, 1420. https://doi.org/10.3390/microorganisms11061420

58. Rybak I, Haas KN, Dhaliwal SK, Burney WA, Pourang A, Sandhu SS, Maloh J, Newman JW, Crawford R, Sivamani RK. Prospective Placebo-Controlled Assessment of Spore-Based Probiotic Supplementation on Sebum Production, Skin Barrier Function, and Acne. J Clin Med. 2023 Jan 23;12(3):895. doi: 10.3390/jcm12030895. 

59. Zeng M, Li Y, Cheng J, Wang J, Liu Q. Prebiotic Oligosaccharides in Skin Health: Benefits, Mechanisms, and Cosmetic Applications. Antioxidants (Basel). 2025 Jun 18;14(6):754. doi: 10.3390/antiox14060754.

60. Rušanac A, Škibola Z, Matijašić M, Čipčić Paljetak H, Perić M. Microbiome-Based Products: Therapeutic Potential for Inflammatory Skin Diseases. Int J Mol Sci. 2025 Jul 14;26(14):6745. doi: 10.3390/ijms26146745.

61. Raza ML, Ali SI, Bhojani A, Zehra R, Zehra R. Microbiome modulation in dermatological disorders: Current insights and therapeutic prospects - A narrative review. Microb Pathog. 2025 Nov;208:107940. doi: 10.1016/j.micpath.2025.107940. 

62. Hairul Hisham HI, Lim SM, Neoh CF, Abdul Majeed AB, Shahar S, Ramasamy K. Effects of non-pharmacological interventions on gut microbiota and intestinal permeability in older adults: A systematic review: Non-pharmacological interventions on gut microbiota/barrier. Arch Gerontol Geriatr. 2025 Jan;128:105640. doi: 10.1016/j.archger.2024.105640.

63. Tuigunov D, Sinyavskiy Y, Nurgozhin T, Zholdassova Z, Smagul G, Omarov Y, Dolmatova O, Yeshmanova A, Omarova I. Precision Nutrition and Gut-Brain Axis Modulation in the Prevention of Neurodegenerative Diseases. Nutrients. 2025 Sep 26;17(19):3068. doi: 10.3390/nu17193068.

64. Seifishahpar M, Kalupahana NS, Kim JH, Moustaid-Moussa N. Interplay Between Dietary Bioactive Compounds and Gut Microbiota in Modulating Obesity-Associated Inflammation and Metabolic Dysfunction. Annu Rev Nutr. 2025 Aug;45(1):141-169. doi: 10.1146/annurev-nutr-111224-024937.

65. Lopes, K.G.; de Souza, M.d.G.C.; Marques Lopes, F.d.A.; da Silva Júnior, V.L.; Carvalho, A.T.P.; Rapozo, D.C.M.; de Lemos Barbosa, C.M.; Bouskela, E.; Castiglione, R.C.; Albano, R.M.; et al. Gut Microbiota, Intestinal Barrier Function, and Metabolism Across Adiposity and Glucose Tolerance. Nutrients 2025, 17, 3380. https://doi.org/10.3390/nu17213380

66. Cai Y, Chen Q. Resveratrol: A Narrative Review Regarding Its Mechanisms in Mitigating Obesity-Associated Metabolic Disorders. Phytother Res. 2025 Feb;39(2):999-1019. doi: 10.1002/ptr.8416.

67. Barrea L, Verde L, Annunziata G, Chedraui P, Petraglia F, Cucalón G, Camajani E, Caprio M, Gorini S, Iorio GG, Di Girolamo R, Carbone L, Chapela S, Frias-Toral E, Muscogiuri G. Effectiveness of Medical Nutrition Therapy in the Management of Patients with Obesity and Endometriosis: from the Mediterranean Diet To the Ketogenic Diet, Through Supplementation. The Role of the Nutritionist in Clinical Management. Curr Obes Rep. 2025 Sep 8;14(1):68. doi: 10.1007/s13679-025-00662-8.

68. Gangwar T, Poonia N, Subudhi RN, Arora V. Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun;398(6):6579-6596. doi: 10.1007/s00210-025-03811-x. 

69. Muttiah, B.; Hanafiah, A. Gut Microbiota and Cardiovascular Diseases: Unraveling the Role of Dysbiosis and Microbial Metabolites. Int. J. Mol. Sci. 2025, 26, 4264. https://doi.org/10.3390/ijms26094264

70. Cheng H, Zhang D, Wu J, Liu J, Zhou Y, Tan Y, Feng W, Peng C. Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review. Phytomedicine. 2023 Oct;119:154979. doi: 10.1016/j.phymed.2023.154979.

71. Drabińska N, Jarocka-Cyrta E. Crosstalk between Resveratrol and Gut Barrier: A Review. Int J Mol Sci. 2022 Dec 3;23(23):15279. doi: 10.3390/ijms232315279.

72. Prakash V, Bose C, Sunilkumar D, Cherian RM, Thomas SS, Nair BG. Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer. Int J Mol Sci. 2024 Mar 16;25(6):3370. doi: 10.3390/ijms25063370. 

73. Mohammadhasani K, Vahedi Fard M, Mottaghi Moghaddam Shahri A, Khorasanchi Z. Polyphenols improve non-alcoholic fatty liver disease via gut microbiota: A comprehensive review. Food Sci Nutr. 2024 Jun 7;12(8):5341-5356. doi: 10.1002/fsn3.4178. 

74. Sim M, Hong S, Jung MH, Choi EY, Hwang GS, Shin DM, Kim CS. Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitamin C status: A randomized, double-blind, placebo-controlled trial. Brain Behav Immun. 2025 Aug;128:179-191. doi: 10.1016/j.bbi.2025.03.032.

75. Li XY, Meng L, Shen L, Ji HF. Regulation of gut microbiota by vitamin C, vitamin E and β-carotene. Food Res Int. 2023 Jul;169:112749. doi: 10.1016/j.foodres.2023.112749. 

76. Marcari AB, Paiva AD, Simon CR, Dos Santos MESM. Leaky Gut Syndrome: An Interplay Between Nutrients and Dysbiosis. Curr Nutr Rep. 2025 Jan 31;14(1):25. doi: 10.1007/s13668-025-00614-7. 

77. Hou ZX, Li WJ, Pi R, Wang HW, Dai MN, Ouyang Y, Li SY. Causal Links Between Gut Microbiota and Vitamin Deficiencies: Evidence from Mendelian Randomization Analysis. Curr Med Sci. 2025 Apr;45(2):321-330. doi: 10.1007/s11596-025-00038-y.

78. Tao Y, Wu M, Su B, Lin H, Li Q, He Y, Zhong T, Xiao Y, Yu X. Host-Gut Microbiota Interactions: Exploring the Potential Role of Vitamin B1 and B2 in the Microbiota-Gut-Brain Axis and Anxiety, Stress, and Sleep Quality. Nutrients. 2025 May 31;17(11):1894. doi: 10.3390/nu17111894.

79. Li J, Duan H, Ramaswamy H, Wang C. A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate. Int J Mol Sci. 2025 Aug 9;26(16):7703. doi: 10.3390/ijms26167703. 

80. Min M, Tarmaster A, Bodemer A, Sivamani RK. The Influence of a Plant-Based Diet on Skin Health: Inflammatory Skin Diseases, Skin Healing, and Plant-Based Sources of Micro- and Macro-Nutrients. Life (Basel). 2024 Nov 7;14(11):1439. doi: 10.3390/life14111439. 

81. Guetterman HM, Huey SL, Knight R, Fox AM, Mehta S, Finkelstein JL. Vitamin B-12 and the Gastrointestinal Microbiome: A Systematic Review. Adv Nutr. 2022 Mar;13(2):530-558. doi: 10.1093/advances/nmab123.

82. Mini-Review Dermatite Atopica 2024 https://www.mitochon.it/dermatite-atopica-rigenerare-i-mitocondri-un-ulteriore-contributo-per-proteggere-la-barriera-epidermica/

83. Mini-Review Rosacea ruolo antiossidanti / vitamine 2025 https://www.mitochon.it/rosacea-la-crescente-attenzione-sul-ruolo-di-antiossidanti-e-vitamine/?v=0d149b90e739

84. Mini-Review Allergie respiratori / cutanee / antiossidanti 2025 https://www.mitochon.it/allergie-respiratorie-e-cutanee-novita-sulle-origini-ossido-infiammatorie-ed-il-contributo-degli-antiossidanti/?v=0d149b90e739

85. Mini-Review Dermatite Seborroica 2024 https://www.mitochon.it/dermatite-seborroica-attualita-sul-contributo-della-dermocosmesi/

86. Zujko-Kowalska K, Jankowska B, Zujko ME. The Antioxidant Power of a Diet May Improve the Quality of Life of Young Women with Acne Vulgaris. Nutrients. 2024 Apr 25;16(9):1270. doi: 10.3390/nu16091270. 

87. Draelos Z, Harper J, Farris PK, Hazan A, Raymond I. A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial for the Efficacy and Safety of a Novel Nutraceutical for Mild-to-Moderate Acne. J Cosmet Dermatol. 2025 May;24(5):e70220. doi: 10.1111/jocd.70220.

88. Ablon G. A 12-week, Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of a Nutraceutical Supplement for Mild to Moderate Non-cystic Acne in Young Adults. J Clin Aesthet Dermatol. 2024 Nov;17(11):24-30.

89. Dawnica Nadora, MS, Ayesha Kothari, BS, Kurt Ashack, MD, Jessica Maloh, ND. Effects of Nutraceutical Supplementation on Acne in Patients with Polycystic Ovary Syndrome: A Systematic Review, JOID, vol. 1, no. 1, May 2025, doi: 10.64550/joid.h5g8c175.

90. Crespi, O.; Rosset, F.; Pala, V.; Sarda, C.; Accorinti, M.; Quaglino, P.; Ribero, S. Cosmeceuticals for Anti-Aging: Mechaniss, Clinical Evidence, and Regulatory Insights—A Comprehensive Review. Cosmetics 2025, 12, 209. https://doi.org/10.3390/cosmetics12050209

91. Mini-Review Melasma: ruolo della cosmeceutica e nutraceutica 2025 https://www.mitochon.it/melasma-quale-contributo/?v=0d149b90e739

92. Mini-Review studio pilota Mitofast 2024 https://www.mitochon.it/mitofast-nuovi-ed-importanti-risultati-da-uno-studio-clinico-preliminare/

93. Mini-Review Resveratrolo - Età biologica / Coenzima Q10 disfunzione mitocondriale 2025 https://www.mitochon.it/resveratrolo-coenzima-q10-eta-biologica-mitocondri-cosa-ce-di-nuovo/?v=0d149b90e739

94. Reyes-Hadsall S, Ju T, Keri JE. Use of Oral Supplements and Topical Adjuvants for Isotretinoin-Associated Side Effects: A Narrative Review. Skin Appendage Disord. 2024 Feb;10(1):1-9. doi: 10.1159/000533963.

95. Morrone P, Caroppo F, De Pedrini A, Colletti A, Baj G. New Perspectives on Nutraceutical Insulin Sensitizing Agents in the Treatment of Psoriasis and Other Dermatological Diseases. Int J Mol Sci. 2025 Aug 4;26(15):7538. doi: 10.3390/ijms26157538.

96. Cui Q, Wang H. Resveratrol in Dermatological Therapy: A Critical Review of Mechanisms, Delivery Innovations, and Clinical Frontiers. Clin Cosmet Investig Dermatol. 2025 Sep 9;18:2229-2242. doi: 10.2147/CCID.S543849.

97. Lain ET, Agrawal N, Ruvolo E, Weise JM, Callender VD. The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review. J Clin Aesthet Dermatol. 2024 Aug;17(8):50-55. 

98. Mini-Review Coenzima Q10 e stanchezza psicofisica 2025 https://www.mitochon.it/coenzima-q10-quale-ruolo-nella-gestione-della-stanchezza-psico-fisica/?v=0d149b90e739

99. Mini-Review Salute della pelle neuroprotezione / Vitamina B12-acido folico 2025 https://www.mitochon.it/notizie-flash-2025/?v=0d149b90e739

100. Mini-Review Salute del sonno - antiossidanti - vitamine 2025 https://www.mitochon.it/salute-del-sonno-quale-contributo-da-antiossidanti-e-vitamine/?v=0d149b90e739

101. Mini-Review Antiaging cognitivo 2025 https://www.mitochon.it/antiaging-cognitivo/?v=0d149b90e739

102. Mini-Review Stress psicofisico - Antiossidanti / Neuroprotettori 2025 https://www.mitochon.it/stress-psicofisico-attualita-sulluso-appropriato-di-antiossidanti-neuroprotettivi/?v=0d149b90e739

103. Mini - Review Benessere e salute mitocodriale 2024 https://www.mitochon.it/obiettivo-benessere-partendo-dalla-salute-dei-mitocondri/

104. Mini-Review Vitamina B12 2023 https://www.mitochon.it/vitamina-b12-nelle-strategie-antiaging/

105. Du F, Alhaskawi A, Zou X, Zhou W, Lu H. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. Int J Vitam Nutr Res. 2025 Aug 11;95(4):39087. doi: 10.31083/IJVNR39087. 

106. Tagore PK, Harit P, Sachan MK, Bharti MK, Singh P, Harit G. Effect of Vitamins B12 and D Deficiency in Thyroid, Skin, Oral, and Respiratory Disease. J Pharm Bioallied Sci. 2025 Jun;17(Suppl 2):S1749-S1751. doi: 10.4103/jpbs.jpbs_300_25.

107. Alharbi NM, AlGhofaili FA, Alsaud JS, Asiri LM, Almutairi SM, Alruqayi DM, Alharbi MK. The Relationship Between Nutritional Anemia and Acne: A Case-Control Study. Cureus. 2023 May 16;15(5):e39109. doi: 10.7759/cureus.39109. 

108. Elgharably N, Al Abadie M, Al Abadie M, Ball PA, Morrissey H. Vitamin B group levels and supplementations in dermatology. Dermatol Reports. 2022 Jul 6;15(1):9511. doi: 10.4081/dr.2022.9511.

109. Mini-Review Antiaging cardiovascolare 2025 https://www.mitochon.it/antiaging-cardiovascolare/?v=0d149b90e739

110. Mini-Review Antiaging muscolare 2025 https://www.mitochon.it/antiaging-muscolare/?v=0d149b90e739