Tra i disturbi urogenitali maschili, quelli della prostata possono colpire anche i giovani adulti?
Si, le attuali statistiche dimostrano che il 30-40% degli uomini ha disturbi della prostata a partire dai 35 anni d’età (1, 145).
E’ stata infatti rilevata una tendenza all’aumento dei sintomi prostatici in età giovanile, quindi non solo dovuti all’avanzamento dell’età (1).
A cosa viene attribuito questo problema?
Le più recenti ricerche mettono in primo piano il precoce invecchiamento biologico dell’organismo (1-5) (Nota 1).
La rivista GeroScience (1) ha illustrato come questo fenomeno aumenti il rischio di ingrossamento della prostata (ipertrofia prostatica benigna), e del cancro prostatico (1-5). L’anticipato invecchiamento cellulare, dei tessuti e degli organi (1), oltre alla predisposizione genetica (6), vengono indicate come le principali origini molecolari e cellulari di queste malattie (1-6).
Oltre ai disturbi della prostata, tali alterazioni sono associate anche ad un maggior rischio cardiovascolare, metabolico, neurodegenerativo e della mortalità (7-14).
Tutte queste malattie hanno infatti in comune molti meccanismi fisiopatologici, es.: disfunzione mitocondriale (14-25), infiammazione cronica (26-47), stress ossidativo (48-52), senescenza cellulare (53-55), alterazioni del microbiota intestinale ecc. (56-66).
Cosa può innescare questi fenomeni dannosi per la prostata?
Vari fattori esterni ed interni all’organismo contribuiscono ad accelerare l’invecchiamento, ed esporre all’insorgenza ed allo sviluppo dei disturbi della prostata anche in età giovanile, es.:
• fumo di tabacco (67, 68, 69);
• eccessivo consumo di alcol (67, 70, 71, 72);
• inquinanti ambientali (73-76);
• inadeguato apporto vitaminico, minerale, fibre ecc.. Abitudini alimentari pro-infiammatorie, come l’elevato apporto lipidico, di cibi ad alto indice glicemico e quelli ultra-processati (77-84). Gli effetti negativi dei cibi ultra-processati sono stati confermati da varie ricerche svolte anche in Italia (85), ed effettuate su ampie fasce della popolazione (84, 86).
• sovrappeso (87-91), obesità di lunga durata, anche nel caso dei giovani adulti (92) e degli adolescenti (93);
• sindrome metabolica, in presenza di insulino-resistenza, elevato rapporto Trigliceridi / Glucosio (94-99), eccesso di grasso addominale (100-101), elevato indice aterogenico plasmatico (rapporto Trigliceridi / Colesterolo HDL) (102);
• prediabete e diabete di tipo 2 (103-118).
• malattie cardiovascolari, es.: ipertensione arteriosa (119), che hanno una relazione bidirezionale con l’accelerazione dell’invecchiamento biologico e con altre condizioni cliniche sistemiche già elencate, come sovrappenso-obesità (119-124).
• periodontite, associata anche ad altre malattie sistemiche, come quelle neurodegenarative (125-130).
• declino delle capacità antiossidanti dell’organismo. Con abbassamento delle concentrazioni dei componenti del sistema enzimatico: catalasi, superossido dismutasi ecc.; e del sistema non-enzimatico: glutatione, coenzima Q10, vitamina C, E, ecc. (131-139).
• abbassamento dei livelli di testosterone (140), non solo collegati all’andropausa (141-144), ma anche derivanti da altre cause, come il sovrappeso e l’obesità (101, 145, 146). L’inadeguato apporto calorico, vitaminico e minerale, eccesso di alcol e caffeina, disturbi metabolici, insufficiente qualità e durata del sonno ecc., possono infatti generare squilibri ormonali già dall’adolescenza (143, 147, 148, 149).
• alti livelli ematici di omocisteina (iperomocisteinemia), comportano l’aumento del rischio cardiovascolare e metabolico. L’insufficiente apporto di vitamine del gruppo B, regolatrici del metabolismo dell’omocisteina, è tra le principali cause dell’iperomocisteinemia (124, 150, 151, 152).
• Esistono molte altre condizioni caratterizzate da infiammazione, stress ossidativo ecc., che possono facilitare il precoce invecchiamento, ed esporre al rischio dei disturbi della prostata. Ne sono un esempio la dermatite atopica, la psoriasi, malattie muscolo scheletriche ecc. (153-167)
Come rallentare l’invecchiamento e ridurre il rischio di dei disturbi prostatici?
Adeguati comportamenti possono proteggere e mantenere la salute della prostata, es.:
• stile di vita, riducendo il più possibile i noti fattori di rischio, es.: sovrappeso / obesità, eccesso di fumo ed alcol, ridotta qualità e durata del sonno, ecc.;
• esercizio fisico praticato con regolarità;
• periodici controlli medici preventivi, ed all’occorrenza adeguate terapie;
• uso mirato di specifici antiossidanti / antinfiammatori e vitamine contenute in nutraceutici ben formulati, di documentata efficacia e qualità (1, 18, 168-178).
Quale contributo possono fornire i nutraceutici Mitochon srl?
Gli ingredienti attivi di Mitofast® e Mitofast B12 (Nota 2) contrastano in modo significativo i danni precoci dell’aging epigenetico e biologico, con l’obiettivo di raggiungere e conservare il benessere dell’organismo, i livelli di energia e vitalità (101, 124, 148, 149, 152, 179-184).
Alcuni ingredienti hanno dimostrato benefici anche nei disturbi della prostata e nelle sue complicazioni, es.:
Resveratrolo
Oltre a contrastare l’ossido-infiammazione, l’integrazione con resveratrolo rallenta l’accelerazione dell’invecchiamento biologico (101, 124, 143, 144, 152, 185-193).
Nei disturbi urogenitali queste attività del resveratrolo risulterebbero vantaggiose nella gestione dell’ipotrofia prostatica benigna e delle sue complicazioni (194-197), nella prevenzione del tumore prostatico, ed in affiancamento alle terapie farmacologiche impiegate nei disturbi della prostata (198-200).
Il resveratrolo svolge inoltre importanti azioni su alcune delle comorbidità che possono facilitare l’insorgenza e lo sviluppo dei disturbi prostatici, es.:
malattie metaboliche (101, 143, 144, 201) cardiovascolari (124), neurodegenerative, stress psicofisico e disturbi del sonno (152, 183, 184, 185, 202), disbiosi intestinale (203-211), malattie osteoarticolari (186, 212, 213).
Coenzima Q10
E’ tra le molecole più studiate ed utilizzate con successo nell’antiaging cutaneo e sistemico, oltre a prevenire ed attenuare molti disturbi correlati all’invecchiamento (186, 188, 214-224).
Nei disturbi urogenitali l’integrazione con coenzima Q10 contribuisce a:
• ridurre significativamente il volume prostatico, anche in associazione alle terapie farmacologiche (226).
• incrementare in modo significativo i livelli ematici di testosterone, ottimizzando le funzioni metaboliche ed ormonali (227, 228).
Vitamina B12 e acido folico
Oltre alle molteplici funzioni, sono vitamine utili per rallentare l’invecchiamento epigenetico-biologico (160, 229-234). Inoltre, modulano i livelli ematici di omocisteina, per prevenire e ridurre l’iperomocisteinemia, noto fattore di rischio per le malattie cardiovascolari, metaboliche e neurologiche, anch’esse reciprocamente legate ai disturbi della prostata (124, 143, 150, 151, 152, 160, 211, 229, 235).
In ambito urogenitale sono documentati:
• un adeguato apporto di acido folico / folati e di vitamina B12 è inversamente associato al rischio di tumore prostatico (236);
• bassi livelli ematici di vitamina B12 sono associati ad un elevato rischio di carenza di testosterone e squilibri del profilo ormonale androgenico (237).
Un ulteriore contributo deriva da altri ingredienti attivi di Mitofast® , come la N-acetilcisteina (238-248) la N-acetilglucosamina (249, 250), le vitamine C ed E (255, 256). Grazie alla loro azione sinergica contro l'invecchiamento, risultano utili anche per attenuare i problemi della prostata (255, 256).
Quali conclusioni pratiche per il benessere maschile?
Sono prioritari i comportamenti e le abitudini di vita adatte a contrastare l’accelerazione dell’invecchiamento biologico.
La prevenzione medica è indispensabile, attraverso opportuni controlli periodici.
In presenza di cause che accelerano l’invecchiamento biologico, assumere in modo mirato specifici integratori alimentari contribuisce a ridurre il rischio di molti disturbi clinici, inclusi quelli che colpiscono la prostata, anche in giovane età (257).
Nota 1
Nello studio pubblicato da GeroScience (1) la valutazione dell’età biologica è stata calcolata con un algoritmo (BioAge https://bioagecalculator.agelessrx.com/) comprendente 10 parametri:
età cronologica, albumina, fosfatasi alcalina, creatinina, glucosio, proteina C-reattiva, percentuale di linfociti, volume corpuscolare medio (MCV), ampiezza di distribuzione dei globuli rossi (RDW), conta dei globuli bianchi (WBC).
PhenoAgeAccel è stata definita come un’età biologica superiore a quella cronologica, quindi accelerata. PhenoAgeDecell è un’età biologica inferiore a quella cronologica.
Nota 2
Integratori antiaging Mitochon srl https://www.mitochon.it/
Mitofast® bit.ly/3VUlGkS e Mitofast B12 bit.ly/4d5ll4P,prevengono ed attenuano i fenomeni biomolecolari dell’invecchiamento cutaneo e sistemico.
• Mitofast® è una formulazione orosolubile, bilanciata e sinergica di: resveratrolo, coenzima Q10, acido folico, vitamina C, N-acetilcisteina (NAC) precursore di glutatione, N-acetilglucosamina (NAG) per la sintesi di acido ialuronico.
• Mitofast B12 è un integratore liquido studiato per somministrare in modo mirato la ciancobalamina, la forma di vitamina B12 farmacologicamente più adatta per l’uso orale.
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153. Furman D, Auwerx J, Bulteau AL, Church G, Couturaud V, Crabbe L, Davies KJA, Decottignies A, Gladyshev VN, Kennedy BK, Neretti N, Nizard C, Pays K, Robinton D, Sebastiano V, Watson REB, Wang MC, Woltjen K. Skin health and biological aging. Nat Aging. 2025 Jul;5(7):1195-1206. doi: 10.1038/s43587-025-00901-6.
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159. Mini-Review Over 50 salute cutanea e benessere psicofisico 2025 https://www.mitochon.it/la-salute-cutanea-negli-over-50-per-il-benessere-psicofisico/?v=0d149b90e739
160. Mini-Review Salute della pelle neuroprotezione / Vitamina B12-acido folico 2025 https://www.mitochon.it/notizie-flash-2025/?v=0d149b90e739
161. Lu WH, Guyonnet S, Raffin J, Bessou-Touya S, Helffer KR, Bianchi P, Digabel JL, Bensadoun P, Lemaitre JM, Barreto PS, Vellas B; IHU HealthAge INSPIRE/Open Science study group. Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20-93: The INSPIRE-T Project. Aging Cell. 2025 Oct;24(10):e70190. doi: 10.1111/acel.70190.
162. Mini-Review Allergie respiratori / cutanee / antiossidanti 2025 https://www.mitochon.it/allergie-respiratorie-e-cutanee-novita-sulle-origini-ossido-infiammatorie-ed-il-contributo-degli-antiossidanti/?v=0d149b90e739
163. Sun J, Fan G, Hu L, Qu ZH, Jiang H. Epigenetic age acceleration and allergic diseases: a bidirectional two-sample Mendelian randomization study. Clin Epigenetics. 2025 Jul 5;17(1):117. doi: 10.1186/s13148-025-01927-8.
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165. Wei W, Qi X, Cheng B, Zhang N, Zhao Y, Qin X, He D, Chu X, Shi S, Cai Q, Yang X, Cheng S, Meng P, Hui J, Pan C, Liu L, Wen Y, Liu H, Jia Y, Zhang F. A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders. Commun Med (Lond). 2024 Dec 18;4(1):266. doi: 10.1038/s43856-024-00706-5.
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177. Ghaderi M, Moradpour F, Moaiery H, Fattahi S, Dehghanbanadaki H, Moradi Y. The Association Between Selenium Levels and Risk of Prostate Cancer: A Systematic Review and Meta-analysis of 16,964 Participants (1980-2024). Asian Pac J Cancer Prev. 2025 Oct 1;26(10):3571-3580. doi: 10.31557/APJCP.2025.26.10.3571.
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179. Mini-Review Motivi per l’Integrazione Mirata 2024 https://www.mitochon.it/4-motivi-1-per-utilizzare-lintegrazione-mirata-contro-linvecchiamento-cutaneo-e-sistemico/
180. Mini-Review studio pilota Mitofast 2024 https://www.mitochon.it/mitofast-nuovi-ed-importanti-risultati-da-uno-studio-clinico-preliminare/
181. Mini-Review umore - energia - vitalità ruolo antiossidanti e vitamine 2025 https://www.mitochon.it/antiossidanti-e-vitamine-quali-effetti-su-umore-energia-e-vitalita/?v=0d149b90e739
182. Mini - Review Benessere e salute mitocodriale 2024 https://www.mitochon.it/obiettivo-benessere-partendo-dalla-salute-dei-mitocondri/
183. Mini-Review Salute del sonno - antiossidanti - vitamine 2025 https://www.mitochon.it/salute-del-sonno-quale-contributo-da-antiossidanti-e-vitamine/?v=0d149b90e739
184. Mini-Review Stress psicofisico - Antiossidanti / Neuroprotettori 2025 https://www.mitochon.it/stress-psicofisico-attualita-sulluso-appropriato-di-antiossidanti-neuroprotettivi/?v=0d149b90e739
185. Mini-Review Resveratrolo effetti neuroprotettivi 2024 https://www.mitochon.it/cervello-e-cognitivita-effetti-neuroprotettivi-del-resveratrolo/
186. Mini-Review Resveratrolo - Età biologica / Coenzima Q10 disfunzione mitocondriale 2025 https://www.mitochon.it/resveratrolo-coenzima-q10-eta-biologica-mitocondri-cosa-ce-di-nuovo/?v=0d149b90e739
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211. Mini-Review Vitamine complesso B - microbiota 2024 https://www.mitochon.it/le-vitamine-del-gruppo-b-cosa-ce-di-nuovo-parte-2/
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229. Mini-Review Vitamina B12 - Acido Folico 2024 https://www.mitochon.it/vitamina-b12-e-acido-folico-cosa-ce-di-nuovo-parte-1/
230. Mini-Review Vitamina B12 https://www.mitochon.it/vitamina-b12-nelle-strategie-antiaging/
231. Mini-Review Acido Folico https://www.mitochon.it/acido-folico-dalla-clinica-allantiaging-attualita-2024/
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238. Mini-Review Glutatione / NAC 2024 https://www.mitochon.it/glutatione-perche-proteggere-le-sue-concentrazioni-cellulari-nellantiaging/
239. Mini-Review N-acetilcisteina 2023 https://www.mitochon.it/n-acetilcisteina-nac-dalla-clinica-allanti-aging/
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autore Andrea Tognelli, Farmacista - Firenze****
